GM-CSF-R-alpha (CD116) Rabbit Polyclonal Antibody（0804-8）

功能

The granulocyte-macrophage colony-stimulating factor receptor also known as CD116 (Cluster of Differentiation 116), is a receptor for granulocyte-macrophage colony-stimulating factor, which stimulates the production of white blood cells. In contrast to M-CSF and G-CSF which are lineage specific, GM-CSF and its receptor play a role in earlier stages of development. The receptor is primarily located on neutrophils, eosinophils and monocytes/macrophages, it is also on CD34+ progenitor cells (myeloblasts) and precursors for erythroid and megakaryocytic lineages, but only in the beginning of their development. It is associated with Surfactant metabolism dysfunction type 4.

背景文献

1. Lanza F, Moretti S, Papa S, et al. Report on the fifth interna tional workshop on human leukocyte differentiation antigens. Boston, November 3 -7, 1993, Haematologica, 1994,79:374～386

2. Lanza F, Castagnar B, Rigolin G, et al. Flow cytometry measurement of GM-CSF receptors in acute leukemic blasts, and normal hemopoietic cells. Leukem ia, 1997, 11: 1700～1710

3. Jubinsky P T, Laurie A S, Nathan D G, et al. Expression and function of the human granulocyte-macrophage colony-stimulating factor receptor alpha sub unit. Blood, 1994, 84:4174～4185

序列相似性

Belongs to the type I cytokine receptor family. Type 5 subfamily.

亚细胞定位

Cell membrane.

UNIPROT #

SwissProt: Q00941 Mouse

别名