ESR1 Rabbit Polyclonal Antibody（0803-1）

功能

Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor that is activated by the sex hormone estrogen. In humans, ERα is encoded by the gene ESR1 (EStrogen Receptor 1). The estrogen receptor (ESR) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The ESR1 protein localizes to the nucleus where it may forms a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.

背景文献

1. Karas RH, Patterson BL, Mendelsohn ME. Human vascular smooth muscle cells contain functional estrogen receptor［J］. Circulation, 1994, 89(5): 1943.

2. Grohe C, Kahlert K, Van EM, et al. Effects of moediprilat on oestrogen-stimulated cardiac fibroblast growth［J］. Br J Pharmacol, 1997,121(7):1350.

序列相似性

Belongs to the nuclear hormone receptor family. NR3 subfamily.

组织特异性

Widely expressed. Isoform 3 is not expressed in the pituitary gland.

翻译后修饰

Phosphorylated by cyclin A/CDK2 and CK1. Phosphorylation probably enhances transcriptional activity. Self-association induces phosphorylation. Dephosphorylation at Ser-118 by PPP5C inhibits its transactivation activity. Phosphorylated by LMTK3 in vitro.; Glycosylated; contains N-acetylglucosamine, probably O-linked.; Ubiquitinated; regulated by LATS1 via DCAF1 it leads to ESR1 proteasomal degradation. Deubiquitinated by OTUB1.; Dimethylated by PRMT1 at Arg-260. The methylation may favor cytoplasmic localization. Demethylated by JMJD6 at Arg-260.; Palmitoylated (isoform 3). Not biotinylated (isoform 3).; Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation, but not for signaling mediated by the nuclear hormone receptor.

亚细胞定位

Nucleus, Cytoplasm, Cell membrane.

UNIPROT #

SwissProt: P03372 Human

别名