Synaptophysin is a 38 kDa glycoprotein present in the membrane of neuronal presynaptic vesicles in brain, spinal cord, retina, vesicles of adrenal medulla, neuromuscular junctions, and endocrine cells. It is also expressed by neuroendocrine cells throughout the body, both normal and neoplastic. Synaptophysin is a useful marker for the identification of normal neuroendocrine cells and neuroendocrine neoplasms.
Synaptophysin Rabbit Polyclonal Antibody
Rabbit Polyclonal Antibody
Synthetic peptide (KLH-coupled) within human Synaptophysin aa 220-280.
Human, Mouse, Rat
WB, IF-Cell, IHC-P, FC
Predicted band size: 34 kDa
Human brain tissue, mouse brain tissue, N2A, rat pancreas tissue, SHG-44.
unconjugated
AB_3068638
Liquid
1ug/ul
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 25% Glycerol. Preservative: 0.05% Sodium Azide.
IgG
Immunogen affinity purified.
WB
1:2000-1:10,000
IF-Cell
1:50-1:200
IHC-P
1:50-1:200
FC
1:50-1:100
Synaptophysin is a 38 kDa glycoprotein present in the membrane of neuronal presynaptic vesicles in brain, spinal cord, retina, vesicles of adrenal medulla, neuromuscular junctions, and endocrine cells. It is also expressed by neuroendocrine cells throughout the body, both normal and neoplastic. Synaptophysin is a useful marker for the identification of normal neuroendocrine cells and neuroendocrine neoplasms.
1. Janz R et al. Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I. Neuron 24:687-700 (1999).
2. Pekkurnaz G et al. Glucose regulates mitochondrial motility via Milton modification by O-GlcNAc transferase. Cell 158:54-68 (2014).
Belongs to the synaptophysin/synaptobrevin family.
Expressed in the brain, with expression in the hippocampus, the neuropil in the dentate gyrus, where expression is higher in the outer half of the molecular layer than in the inner half, and in the neuropil of CA4 and CA3.
Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
Cytoplasmic vesicle, Membrane, Synapse, Synaptosome.
SwissProt: P08247 Human
SwissProt: Q62277 Mouse
SwissProt: P07825 Rat
Major synaptic vesicle protein p38 antibody
MRX96 antibody
MRXSYP antibody
Syn p38 antibody
Synaptophysin antibody
Syp antibody
SYPH antibody
SYPH_HUMAN antibody
SypI antibody
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