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Anti-Bcl-2 antibody[STJ98587]
  • Anti-Bcl-2 antibody[STJ98587]
  • Anti-Bcl-2 antibody[STJ98587]
  • Anti-Bcl-2 antibody[STJ98587]

Anti-Bcl-2 antibody[STJ98587]

Product nameAnti-Bcl-2 antibodyShort DescriptionRabbit polyclonal against Bcl-2DescriptionBcl-2 is a protein encoded by the B

  • 宿主:Rabbit
  • 克隆性:Polyclonal
  • 种属:Mouse, Rat
  • 应用:ELISA, IHC-p, WB
  • 规格:20ul,50ul,100ul,200ul
  • 联系:钱女士 15301726783
Product nameAnti-Bcl-2 antibody
Short DescriptionRabbit polyclonal against Bcl-2
DescriptionBcl-2 is a protein encoded by the BCL2 gene which is approximately 26, 2 kDa. Bcl-2 is localised to the mitochondrion outer membrane, endoplasmic reticulum membrane and nucleus membrane. It is involved in PEDF induced signalling, the TGF-Beta pathway and TNFR1 pathway. It suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. It regulates cell death by controlling the mitochondrial membrane permeability and appears to function in a feedback loop system with caspases. It inhibits caspase activity either by preventing the release of cytochrome C from the mitochondria and/or by binding to the apoptosis-activating factor. Bcl-2 is expressed in a variety of human tissues. Mutations in the BCL2 gene may result in follicular lymphoma. STJ98587 was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This antibody detects endogenous Bcl-2 proteins.
ApplicationsELISA, IHC-p, WB
Dilution rangeWB 1:500-2000
ELISA 1:10000-20000
IHC 1:50-300
SpecificityBcl-2 polyclonal antibody detects endogenous levels of Bcl-2
Protein NameApoptosis Regulator Bcl-2
ImmunogenSynthesized peptide derived from Bcl-2
Immunogen Region10-90 aa
Storage InstructionStore at-20°C, and avoid repeat freeze-thaw cycles.
NoteFOR RESEARCH USE ONLY (RUO).
HostRabbit
ClonalityPolyclonal
ReactivityMouse, Rat
ConjugationUnconjugated
Concentration1 mg/ml
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
IsotypeIgG
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID596
Gene SymbolBCL2
Database LinksHGNC:990
OMIM:151430
Alternative NamesAnti-Apoptosis Regulator Bcl-2 antibody
Anti-BCL2 antibody
FunctionSuppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release.
Post-translational ModificationsPhosphorylation/dephosphorylation on Ser-70 regulates anti-apoptotic activity. Growth factor-stimulated phosphorylation on Ser-70 by PKC is required for the anti-apoptosis activity and occurs during the G2/M phase of the cell cycle. In the absence of growth factors, BCL2 appears to be phosphorylated by other protein kinases such as ERKs and stress-activated kinases. Phosphorylated by MAPK8/JNK1 at Thr-69, Ser-70 and Ser-87, wich stimulates starvation-induced autophagy. Dephosphorylated by protein phosphatase 2A (PP2A).; Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity, causes the release of cytochrome c into the cytosol promoting further caspase activity.; Monoubiquitinated by PRKN, leading to increase its stability. Ubiquitinated by SCF(FBXO10), leading to its degradation by the proteasome.
Cellular LocalizationMitochondrion Outer Membrane
Single-Pass Membrane Protein
Nucleus Membrane
Endoplasmic Reticulum Membrane
Tissue SpecificityExpressed in a variety of tissues.
Swiss-Prot KeyBCL2_HUMAN

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